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1.1.1 Enlarged thyroid

1.1.2 Neck mass

1.2 Epistaxis, uncontrolled by usual methods

1.3 Facial Mass, swelling, pain or tenderness

1.4.1 Mass detected in a child (<18 years)

1.4.2 Mass detected in an adult 40 or older

1.4.3.1 Growing, OR

1.4.3.2 Larger than 3cm. OR

1.4.3.3 Mass not responding to antibiotic therapy

1.4.4 Recurrence, or new mass, at site of previously treated tumor

1.4.5 Thyroid eye disease (including myopathy )

1.5 Orbital or periorbital mass

1.6 Proptosis

1.7 Unilateral exophthalmos or enophthalmous

1.8 Vision loss

2.1.1 Breast or lung cancer

2.1.2 History of radiation therapy to the chest, breast or axilla

2.1.3 Numbness

2.1.4 Palpable mass

2.1.5 Paresthesias

2.1.6 Radiating pain

2.1.7 Weakness of upper extremity

2.1.8.1 Devin K. Binder, M.D., Ph.D.; Justin S. Smith, M.D., Ph.D.; Nicholas M. Barbaro, M.D Primary Brachial Plexus Tumors: Imaging, Surgical, and Pathological Findings in 25 Patients Neurosurgical Focus Medscape Radiology accessed 12/28/08

2.1.8.2 Bowen B, Seidenwurm DJ, Davis P, et al, Expert Panel on Neurologic Imaging, American College of Radiology, Appropriateness Criteria, Plexopathy, accessed at http://www.acr.org/SecondaryMainMenuCategories/quality_safety/app_criteria/pdf/ExpertPanelonNeurologicImaging/PlexopathyDoc12.asp x 12/28/08

2.1.8.3 ACR Appropriateness Criteria Plexopathy p10 Accessed 12/28/08

2.2.1 Marcus Gunn pupil Asymmetric pupillary response to light

2.2.2 Ophthalmoplegia paralysis of some or all of the muscles of the eye

2.2.3 Pain with movement of the eye

2.2.4 Scotoma

Balcer, LJ. Clinical practice. Optic neuritis. N Engl J Med 2006; 354:1273

Riordan-Eva P. Chapter 7. Disorders of the Eyes & Lids. In: McPhee SJ, Papadakis MA, Rabow MW, eds. CURRENT Medical Diagnosis & Treatment 2012. New York: McGraw-Hill; 2012. http://www.accessmedicine.com/content.aspx?aID=2002. Accessed November 25, 2012.

Hickman SJ, Toosy AT, Miszkiel KA, Jones SJ, Altmann DR, MacManus DG, Plant GT, Thompson AJ, Miller DH Visual recovery following acute optic neuritis–a clinical, electrophysiological and magnetic resonance imaging study. J Neurol. 2004;251(8):996

Rizzo JF 3rd, Andreoli CM, Rabinov JD Use of magnetic resonance imaging to differentiate optic neuritis and nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 2002;109(9):1679.

Kupersmith MJ, Alban T, Zeiffer B, Lefton D Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance. Brain. 2002;125(Pt 4):812

G. R. Bonhomme, A. T. Waldman, L. J. Balcer, A. B. Daniels, G. I. Tennekoon, S. Forman, S. L. Galetta, and G. T. Liu Pediatric optic neuritis: Brain MRI abnormalities and risk of multiple sclerosis Neurology, Mar 2009; 72: 881 – 885.

2.3 Orbital cellulitis

2.4.1 Elevated serum calcium or parathyroid hormone (PTH)

2.4.2 Mass by physical examination or other imaging.

2.4.3 Nuclear or Ultrasound examinations nondiagnostic

2.5.1 Acutely swollen and painful gland

2.5.2 Mass by physical examination or other imaging.

2.5.3 Recurrent infections

2.5.4.1 Nicholas A. Drage, Jackie E. Brown, Michael P. Escudier, and Mark McGurk Interventional Radiology in the Removal of Salivary Calculi Radiology January 2000 214:139-142

2.5.4.2 Varghese, JC, Thornton, F, Lucey, BC, Walsh, M, Farrell, MA, Lee, MJ A prospective comparative study of MR sialography and conventional sialography of salivary duct disease Am. J. Roentgenol. 1999 173: 1497-1503 Does not support the use of MR fo discover stones2.5.4.2 Varghese, JC, Thornton, F, Lucey, BC, Walsh, M, Farrell, MA, Lee, MJ A prospective comparative study of MR sialography and conventional sialography of salivary duct disease Am. J. Roentgenol. 1999 173: 1497-1503 Does not support the use of MR fo discover stones

2.5.4.3 Kalinowski, Marc, Heverhagen, Johannes T., Rehberg, Elisabeth, Klose, Klaus Jochen, Wagner, Hans-Joachim Comparative Study of MR Sialography and Digital Subtraction Sialography for Benign Salivary Gland Disorders AJNR Am J Neuroradiol 2002 23: 1485-1492 Also favors sialography as more accurate

2.6 Scleritis inflammation of the dense fibrous opaque white outer coat enclosing the eyeball except the part covered by the cornea

2.7 Uveitis inflammation of the middle layer of the eye consisting of the iris and ciliary body together with the choroid coat — called also vascular tunic

2.8.1.1 Chin, Shy-Chyi, Edelstein, Simon, Chen, Cheng-Yu, Som, Peter M. Using CT to Localize Side and Level of Vocal Cord Paralysis Am. J. Roentgenol. 2003 180: 1165-1170

2.8.1.2 Glazer, HS, Aronberg, DJ, Lee, JK, Sagel, SS Extralaryngeal causes of vocal cord paralysis: CT evaluation Am. J. Roentgenol. 1983 141: 527-531

3.1.1 Enlarged thyroid

3.1.2 Neck mass

3.2 Nasal endoscopy suggests tumor

3.3.1 Mass detected in a child (<18 years)

3.3.2 Mass detected in an adult 40 or older

3.3.3.1 Growing, OR

3.3.3.2 Larger than 3cm. OR

3.3.3.3 Mass not responding to antibiotic therapy

3.3.4 Recurrence, or new mass, at site of previously treated tumor

3.3.5 Thyroid eye disease (including myopathy )

3.4 Optic atrophy by fundoscopic examination

3.5 Orbital or periorbital mass

3.6 Papilledema by fundoscopic examination

3.7 Unilateral exophthalmos or enophthalmous

3.8.1.1 Chin, Shy-Chyi, Edelstein, Simon, Chen, Cheng-Yu, Som, Peter M. Using CT to Localize Side and Level of Vocal Cord Paralysis Am. J. Roentgenol. 2003 180: 1165-1170

3.8.1.2 Glazer, HS, Aronberg, DJ, Lee, JK, Sagel, SS Extralaryngeal causes of vocal cord paralysis: CT evaluation Am. J. Roentgenol. 1983 141: 527-531

4.1 Orbital tumor by Physical exam or imaging

5.1.1 Initial staging and evaluation

5.1.2 Interval follow up after treatment

5.1.3 Restaging

5.1.4 Worsening clinical situation

5.2 Pre- or Post-operative evaluation

5.3 Recurrent sinusitis after appropriate antibiotic therapy, nasopharyngeal tumor suspected

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